Israel Cook Russell, 1852-1906

Dmd052985 1852..1858

Aldehyde oxidase (AOX) is a cytosolic enzyme expressed across a wide range of species, including guinea pig and rhesus monkey. These species are believed to be the best preclinical models for studying human AOX-mediated metabolism. We compared AOX activity in rhesus monkeys, guinea pigs, and humans using phthalazine and N-[2-(dimethylamino)ethyl]acridone-4-carboxamide (DACA) as substrates and r...

Dmd053405 1906..1913

Carbinol [4,49-(hydroxymethylene)dibenzonitrile] is the main phase 1 metabolite of letrozole, a nonsteroidal aromatase inhibitor used for endocrine therapy in postmenopausal breast cancer. We elucidated the contribution of UDP-glucuronosyltransferase (UGT) isoforms on the glucuronidation of carbinol. Identification of UGT isoforms was performed using a panel of recombinant human UGT enzymes. Ki...

Pierre Curie, 1859–1906

The year 2006 marked 100 years since the death of Pierre Curie. It is therefore appropriate that we remember his life and his work, which was cut short by his untimely death from an accident on the Pont Neuf, Paris, on April 19, 1906. He had already accomplished much during his life, both before the discovery of radium with Marie Curie, in work co-authored with his brother Jacques on piezoelect...

Christian A. Herter, 1906

Hans Asperger (1906-1980)

Hans Asperger studied mental abnormalities in children in Vienna, Austria, in the early twentieth century. Asperger was one of the early researchers who studied the syndrome that was later named after him, Asperger's Syndrome. Asperger described the syndrome in his 1944 publication Die Autistischen Psychopathen im Kindesalter (Autistic Psychopathy in Childhood). At that time, the syndrome was c...